One player who seems to handle such 'imbalanced' positions well is Gawain Jones. I've seen him do it a couple of times with my own eyes, and in the final round of the 2012 European Championship he decided that giving up a piece for 3 pawns was the right strategy. Of course this is a no-brainer in the ending, but in this case the game was still in the opening stages, where such sacrifices are frowned upon. However an exchange of queens made his task a little easier, and eventually the pawns triumphed.
Ernst,Sipke - Jones,Gawain [A83]
European Championship Plovdiv, 2012